HPLC UHPLC Osmometry & etc.


Wissenschaftliche Gerätebau Dr. Ing. Herbert Knauer GmbH is one of the well-established manufactures of HPLC instruments, SMB and osmometry. The product portfolio includes the smallest HPLC system of the world, UHPLC systems, analytical and semi-preparative HPLC instruments and SMB systems for the extraction of up to 1,000 kg of pure substance per year.

The sources of success are numerous world’s firsts that have won more than 20 awards for innovation. Company strives to grow continuously, to expand expertises and to discover new market opportunities.



Analytical HPLC




High performance liquid chromatography (HPLC) today has become one of most important methods in instrumental analysis. HPLC can be used for a variety of applications due to the wide range of separation columns and detection principles available. Read More >>





Compared to standard HPLC, systems for ultra high performance liquid chromatography (UHPLC) offer superior results in terms of resolution and speed allowing for separation of more complex samples and for faster results.

UHPLC requires columns with smaller particle sizes (< 2 µm) or core-shell material, a minimized system volume, increased pressure stability (up to 1000 bar), high response detection, and faster data acquisition. Read More >>





Biochromatography is about the separation and purification of biomolecules such as proteins and peptides. The wetted parts of a biochromatography system need to be of biocompatible material and resistant to all buffer solutions.

The biochromatography techniques covered by KNAUER Bioline equipment include size exclusion, ion exchange, hydrophobic interaction, affinity, reversed phase chromatography, and more. Read More >>





KNAUER is one of the pioneers in the field of osmometry instruments. We offer:

  • Semi-micro freezing point osmometers for the determination of total osmolality of biological fluids and other aqueous liquids
  • Vapor pressure osmometers especially for polymer characterization


Preparative HPLC




The aim of preparative HPLC is to isolate the maximum amount of a certain product at a desired purity in a minimum of time. It ranges from the purification of milligrams for further investigation up to production scale purifications.  

The requirements for a preparative HPLC system differ from analytical systems regarding sensitivity, flow rates, and robustness. The main difference however, is the fraction collection control: is crucial for the quality of the product. Read More >>

Purification solutions




KNAUER has been active in the field of continuous chromatography for many years. As one of the pioneers in SMB chromatography, we developed the smallest SMB system in the world for the separation of two-component mixtures in 1996. Based on our long experience, we offer systems that purify a target compound with maximum purity and maximum recovery in minimal time.

Let us know your purification task - we will find the right purification solution for you!


Sample preparation




Before the chromatography process can start, a wide range of sample matrices including foodstuffs, tussues, plants and environmental samples need to be cleaned. Especially high molecular weight compounds such as lipids, polymers, co-polymers, proteins, natural resins, cellular components and steroids should be dispersed from the sample in order to protect the chromatography system from blockings. Read More >>


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